LX2343
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
LX2343 是一种BACE1酶抑制剂，IC50值为11.43±0.36 μM。LX2343是一种非ATP竞争性的PI3K抑制剂，IC50为15.99±3.23 μM。LX2343 刺激自噬促进Aβ清除。LX2343 (5-20μM)剂量依赖性地减少HEK293-APPsw和 CHO-APP细胞中Aβ的积累，并促进SH-SY5Y细胞和原代星形胶质细胞中的Aβ清除。LX2343通过抑制Aβ产生和促进清除来改善APP/PS1转基因小鼠的认知功能障碍，这突出了LX2343在治疗AD中的潜力。APP/PS1小鼠表达嵌合人瑞典突变体APP和突变体人早老素1蛋白，被广泛用作AD痴呆的有效动物模型[1]。
参考文献：
[1]. Guo XD, Sun GL, Zhou TT, Xu X, Zhu ZY, Rukachaisirikul V, Hu LH, Shen X. Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance. Acta Pharmacol Sin. 2016 Sep;37(10):1281-1297. doi: 10.1038/aps.2016.80. Epub 2016 Aug 29. PMID: 27569389; PMCID: PMC5057240.
| Storage | Store at -20°C |
| M.Wt | 474.91 |
| Cas No. | 333745-53-2 |
| Formula | C22H19ClN2O6S |
| Solubility | ≥43.2 mg/mL in DMSO |
| Chemical Name | N-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(NC1=CC=C(OCO2)C2=C1)CN(C3=CC(Cl)=CC=C3OC)S(=O)(C4=CC=CC=C4)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
