Latrunculin B
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥3894.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Latrunculin B is a cell-permeable actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin[1].
Although the activity of latrunculin B is slightly weaker than latrunculin A, its short-term effect is comparable to latrunculin A. The presence of serum in the medium always containing latrunculin B gradually causes the inactivation of latrunculin B, so that the induced changes are instantaneous. Because of this, latrunculin B may produce fewer undesirable physiological effects than latrunculin A, making it more suitable for short-term studies[2].
References:
[1]. Wakatsuki T, Schwab B, Thompson N C, et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. Journal of Cell Science, 2000, 114(5): 1025-1036.
[2]. Spector I, Schochet N R, Blasberger D, et al. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. comparison with cytochalasin D. Cell Motility and the Cytoskeleton, 1989, 13(3): 127-144.
产品性质
| 物理外观 | Colourless film |
| CAS号 | 76343-94-7 |
| 分子式 | C20H29NO5S |
| 分子量 | 395.5 |
| 化学名称 | 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone |
| 溶解度 | ≤25mg/ml in DMSO |
| SMILES | C[C@@H](CC[C@H](C[C@H](C1)O2)O[C@]1([C@H](CS1)NC1=O)O)/C=C\CC/C(\C)=C\C2=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | Latrunculin B 是一种抗菌海洋生物碱，是一种抑制剂。Latrunculin B 可调节肺静脉电生理特征，减轻拉伸引起的心律失常。 |
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