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Laropiprant

拉罗皮兰,各拉西酮
Catalog No.
A3538
DP1受体拮抗剂
组合的产品项目
规格价格库存 数量
5mg
¥ 1,370.00
Ship with 10-15 days
10mg
¥ 1,979.00
Ship with 10-15 days
50mg
¥ 7,101.00
Ship with 10-15 days
100mg
¥ 8,623.00
Ship with 10-15 days

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A

背景

Laropiprant(Cardaptive; MK 0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively. Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt435.9
Cas No.571170-77-9
FormulaC21H19ClFNO4S
SynonymsCardaptive; MK 0524; MK-0524,Laropiprant
SolubilitySoluble in DMSO
Chemical Name2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
SDFDownload SDF
Canonical SMILESCS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)C(CC3)CC(=O)O
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

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化学结构

Laropiprant