Lamin fragment

Lamin片段（核纤层蛋白片段）的多肽序列为Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp。

核纤层蛋白是V型中间丝，根据在细胞周期中的同源性序列、生物化学性质和细胞定位，可将其分为A型或B型，A型包括核纤层蛋白A和C，B型包括核纤层蛋白B1和B2。核纤层蛋白片段几乎涵盖了所有的α螺旋构象，由非α螺旋连接子分隔成多个α螺旋结构域，这些α螺旋结构域的氨基酸序列和长度高度保守。

核纤层蛋白是中间丝型的蛋白质，是核纤层的主要组成部分，核纤层是内核膜底层纤维状蛋白网络。核纤层蛋白也可以以弥漫性或斑点模式定位在细胞核内，在DNA复制、染色质组织、核孔复合体的空间排列、核生长以及核膜蛋白的锚固中发挥作用。

参考文献：

1.  The Cell: A Molecular Approach, Cooper & Hausman. 5th Edition. Pg. 357

2.  Ayelet Margalit, Sylvia Vlcek, Yozef Gruenbaum, Roland Foisner (2005). Breaking and Making of the Nuclear Envelope. Journal of Cellular Biochemistry 95, 454-465

3.  Bruce Alberts, et al. Molecular Biology of the Cell (4th edition). Garland Science 676-677

4.  Geoffrey M. Cooper, Robert E. Hausman. The Cell, A Molecular Approach (4th edition). Sinauer Associates 356-360

5.  Goldman et al.(2002). "Nuclear lamins: building blocks of nuclear architecture". Genes and Development 16,533-547

6.  Joanna M. Bridger, Nicole Foeger, Ian R. Kill, Harald Herrmann (2007). The Nuclear Lamina: both a structural framework and a platform for genome organization. FEBS Journal 274, 1354–1361

7.  Nico Stuurman, Susanne Heins, Ueli Aebi (1998). Nuclear Lamins: Their Structure, Assembly and Interactions. Journal of Structural Biology 122, 42-46

8.  Tripathi K, Muralikrishna B and Parnaik VK (2009) Differential dynamics and stability of lamin A rod domain mutants IJIB, 5(1), 1-8

9.  Yozef Gruenbaum, Katherine L. Wilson, Amnon Harel, Michal Goldberg, Merav Cohen (2000). Nuclear Lamins – Structural Proteins with fundamental functions. Journal of Structural Biology129, 313-323