KN-62（1-[N,O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosy]-4-phenylpiperazine）是一种高选择性的钙依赖性钙调蛋白激酶II（CAMKII）抑制剂，与CAMKII的钙调蛋白结合位点相结合，因而不能抑制其它类的钙调蛋白敏感激酶。在以前的研究中，KN-62通过质膜上L型Ca2+通道阻断Ca2+内流，抑制由内在薄层（HIT）细胞的异质连接所调节的胰岛素分泌和斯钙素-1（STC-1）肠内分泌细胞中胆囊收缩素的分泌。KN-62还抑制骨骼肌中胰岛素和缺氧刺激的葡萄糖转运活性，分别抑制了46%和40%。

参考文献：
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