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JGB1741

 
Catalog No.
C3888
SIRT1抑制剂
组合的产品项目
规格价格库存 数量
1mg
¥ 1,245.00
Ship with 10-15 days
5mg
¥ 4,170.00
Ship with 10-15 days
10mg
¥ 7,420.00
Ship with 10-15 days
25mg
¥ 16,141.00
Ship with 10-15 days

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A

背景

JGB1741 is a small molecule SIRT1 inhibitor [1].

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes which are involved in deacetylating lysine residue on multiple proteins. The sirtuins show highly conservation from archaebacteria to eukaryotes. The mammalian sirtuins SIRT1–SIRT7 have been implicated in a variety of cellular functions, such as gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis [2].

In vitro: JGB1741 potently inhibited the proliferation of human metastatic breast cancer cells, MDA-MB 231. JGB1741 showed antitumor effects on three different cancer cell lines, K562, HepG2 and MDA-MB 231 with an IC50 of 1, 10 and 0.5 μM, respectively. JGB1741-induced apoptosis has been associated with increase in cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP [1].

References:
[1] Kalle A M, Mallika A, Badiger J, et al.  Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells[J]. Biochemical and biophysical research communications, 2010, 401(1): 13-19.
[2] Yamamoto H, Schoonjans K, Auwerx J.  Sirtuin functions in health and disease[J]. Molecular Endocrinology, 2007, 21(8): 1745-1755.

文献引用

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt440.6
Cas No.1256375-38-8
FormulaC27H24N2O2S
SynonymsILS-JGB-1741
Solubility≤0.2mg/ml in DMSO;0.14mg/ml in dimethyl formamide
Chemical Name4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide
SDFDownload SDF
Canonical SMILESOC1=C(/C=N/C2=C(C(NCC3=CC=CC=C3)=O)C(CCCC4)=C4S2)C(C=CC=C5)=C5C=C1
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

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批次:

化学结构

JGB1741

相关生物数据

JGB1741