Jasplakinolide
稳定预形成的肌动蛋白丝并抑制其去组装
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 50ug | ￥5925.00 | 7-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Jasplakinolide, a cyclodepsipeptide originally isolated from the marine sponge, Jaspis johnstoni, is a potent inducer of actin polymerization, which also stabilizes pre-formed actin filaments. Jasplakinolide may exert its cytotoxic effect by binding to F-actin. Compared with Ca2+-actin, jasplakinolide shows a much greater effect on Mg2+-actin, and binds to F-actin competitively with phalloidin with a Kd value of ~ 15 nM. Jasplakinolide exhibits both fungicidal and antiproliferative activity. In addition, jasplakinolide is membrane-permeable, which makes it a commonly used tool in cell biology, when actin polymerization or actin filament stabilization has to be achieved.
References:
1. Bubb MR, Senderowicz AM, Sausville EA, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. Journal of Biological Chemistry, 1994, 269(21): 14869-14871.
2. Holzinger A. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods in Molecular Biology, 2009, 586: 71-87.
产品性质
| 物理外观 | An off- |
| CAS号 | 102396-24-7 |
| 分子式 | C36H45BrN4O6 |
| 分子量 | 709.67 |
| 化学名称 | (4R,7R,10S,13R,17R,19S,E)-7-((2-bromo-1H-indol-3-yl)methyl)-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetraone |
| 溶解度 | Soluble in DMSO |
| SMILES | BrC(NC1=CC=CC=C21)=C2C[C@H](C(N[C@@H](C(C=C3)=CC=C3O)CC(O[C@@H](C)C[C@@H](C)C=C(C)C[C@@H](C)C(N[C@H]4C)=O)=O)=O)N(C)C4=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
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