Helioxanthin derivative 5-4-2
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Helioxanthin derivative 5-4-2是helioxanthin (ACH126447)的类似物,是HBV\HSV-1和HSV-2的小分子抑制剂,EC50值分别为0.08 μM\0.29 μM和0.16 μM [1].
Helioxanthin derivative 5-4-2是一种内酰胺,对HBV的 DNA\RNA及病毒蛋白表达具有抑制作用[2].Helioxanthin derivative 5-4-2具有显著的抗病毒活性,对HBV(肝炎B 病毒), HSV-1(1型单纯疱疹病毒)和HSV-2(2型单纯疱疹病毒)的EC50值分别为0.08 μM\0.29 μM 和0.16 μM [1] .另外,Helioxanthin derivative 5-4-2通过对必需转录因子的转录后下调,抑制HBV复制[3].Helioxanthin derivative 5-4-2具有有效抗HCV(肝炎病毒C)活性,1.0 μM能够抑制 55%,3.0 μM能够抑制80% [1].
参考文献：
[1]. Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2]. Li Y1, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, ChengYC.Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother. 2005;16(3):193-201.
[3]. Stein LL1, Loomba R. Drug targets in hepatitis B virus infection. Infect Disord Drug Targets. 2009 Apr;9(2):105-16.
| Storage | Store at -20°C |
| M.Wt | 347.32 |
| Cas No. | 203935-39-1 |
| Formula | C20H13NO5 |
| Solubility | Soluble in DMSO |
| Chemical Name | 10-(benzo[d][1,3]dioxol-5-yl)-9H-[1,3]dioxolo[4',5':3,4]benzo[1,2-f]isoindol-7-ol |
| SDF | Download SDF |
| Canonical SMILES | OC1=NCC2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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