Guvacoline (hydrobromide)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | 请咨询 | 10-15工作日发货 | |
| 10mg | 请咨询 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Target: atrial and ileal muscarinic receptors
IC50: 2.1 mM for growth inhibition of human buccal epithelial cells
Guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. Guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.
In Vitro: In human buccal epithelial cells, Guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the IC50 value of 2.1 mM. Besides, Guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mM Guvacoline caused 25% decrease) and increase the number of single strand breaks [1].
In Vivo: No data available recently.
Clinical trial: No data available recently.
Reference:
[1] K. Sundqvist, Y. Liu, J. Nair, et al. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Research 49(19), 5294-5298 (1989).
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 17210-51-4 |
| 分子式 | C7H11NO2·HBr |
| 分子量 | 222.1 |
| 小分子别名 | Guvacoline hydrobromide |
| 化学名称 | 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide |
| 溶解度 | ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide |
| SMILES | COC(C1=CCCNC1)=O.Br |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 氢溴酸古伐喹啉是一种吡啶生物碱，可作为心房和回肠的弱完全激动剂。 |
生物相关数据
质量控制
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Gheddar L, Ricaut FX, et al. "Testing for Betel Nut Alkaloids in Hair of Papuans Abusers using UPLC-MS/MS and UPLC-Q-Tof-MS." J Anal Toxicol. 2019 Jun 19. pii: bkz045. PMID:31263904
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