GSK2838232
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
GSK2838232是HIV-1成熟的抑制剂[1][2].
HIV-1成熟的抑制剂破坏HIV-1蛋白酶对HIV-1 gag蛋白直接前体的裂解.成熟抑制剂与gag蛋白结合,导致不成熟\非感染性的病毒颗粒形成,其不能感染其它细胞.此外,成熟抑制剂抑制HIV感染的耐受性.
GSK2838232是HIV-1成熟的抑制剂,具有广谱的抗病毒活性,包括bevirimat抗性菌株[1].GSK2838232用于治疗慢性艾滋病毒感染.HIV阴性个体的I期研究已经完成.使用5\10或20 mg单一剂量的GSK2838232评价初始安全性\耐受性\药代动力学特性以及食物和利托那韦对GSK2838232的生物利用度和药代动力学的效应[2].
参考文献:
[1]. Olender SA, Taylor BS, Wong M, et al. CROI 2015: Advances in Antiretroviral Therapy. CROI 2015 Highlights: Antiretroviral Therapy Volume 23 Issue 1 March/April 2015.
[2]. Horn T, Collins S. The Antiretroviral Pipeline. Antiretrovirals, 2014 PIPELINE REPORT.
Storage | Store at -20°C |
M.Wt | 809.56 |
Cas No. | 1443461-21-9 |
Formula | C48H73ClN2O6 |
Solubility | Soluble in DMSO |
SDF | Download SDF |
Canonical SMILES | CC(C(C(C[C@@]([C@](O)([H])CN(CC1=CC=C(Cl)C=C1)CCN(C)C)2CC[C@]34C)=O)=C2[C@@]3([H])CC[C@]5([H])[C@]6(CC[C@@](OC(CC(C)(C(O)=O)C)=O)([H])C(C)(C6([H])CC[C@]54C)C)C)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |