GnRH Associated Peptide (1-13), human

序列：Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val

将编码人促性腺激素释放激素（GnRH）的前体蛋白的cDNA序列构建进表达载体转入细菌中，在细菌中合成含有56个氨基酸的GnRH相关肽（GAP）。GAP是催乳素分泌的有效抑制剂，可以刺激促性腺激素的释放。对GAP序列相关多肽的主动免疫可导致催乳素分泌的增加。

促性腺激素释放激素（GnRH）在脊椎动物繁殖过程中发挥重要作用。从下丘脑神经元释放的十肽控制体内促性腺激素水平，其反过来调节性腺状态。促性腺激素释放激素（GnRH）在脊椎动物中广泛表达并具有保守性，显示了它的重要性。此外，促性腺激素释放激素相关肽（GAP）与GnRH共同分泌释放进入垂体门静脉血液。

参考文献：
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