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Glucagon (19-29), human

 
Catalog No.
A1019
强效的Ca2+/Mg2+-ATPase抑制剂。
组合的产品项目
规格价格库存 数量
5mg
¥ 381.00
现货
10mg
¥ 636.00
现货
25mg
¥ 890.00
现货

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A

背景

Glucagon是由胰腺分泌的一种肽类激素,氨基酸序列为NH2-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-COOH,可增加体内血糖水平。胰高血糖素的作用与胰岛素相反,胰岛素可以降低血糖含量。促分泌素可诱导胰岛素释放,Miniglucagon(胰高血糖素19-29)通过钙离子途径高效的抑制这个过程。Miniglucagon是胰岛生理学的一种新型的局部调节剂。在2型糖尿病中观察到,这种肽在β细胞中诱导的异常抑制可导致胰岛素分泌受损。Miniglucagon是胰高血糖素正性肌力作用的一种成分。证据表明,胰高血糖素在心脏收缩过程中发挥正性肌力作用,胰高血糖素转变成miniglucagon的过程对于正向肌力作用的产生是必不可少的。

A1019_1
参考文献:

1. Reece J, Campbell N (2002). Biology. San Francisco: Benjamin Cummings. ISBN 0-8053-6624-5.

2. Stéphane Dalle, Ghislaine Fontés, Anne-Dominique Lajoix2, Laurence LeBrigand, René Gross, Gérard Ribes, Michel Dufour, Léo Barry, Dung LeNguyen and Dominique Bataille, Miniglucagon (Glucagon 19-29) A Novel Regulator of the Pancreatic Islet Physiology, doi:10.2337/diabetes.51.2.406Diabetes February 2002 vol. 51 no. 2406-412

3. Pavoine C, Brechler V, Kervan A, Blache Kervan, Le-Nguyen D, Laurent S, Bataille D, Pecker F (1991) Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol 260:C993–C999.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1352.51
Cas No.64790-15-4
FormulaC61H89N15O18S
SynonymsH2N-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Solubilityinsoluble in EtOH; insoluble in H2O; ≥135.2 mg/mL in DMSO
Chemical NameGlucagon (19-29), human
SDFDownload SDF
Canonical SMILESCC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(C)N
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试验操作

Cell experiment:[1]

Cell lines

MIN6 cells

Reaction Conditions

0.01 ~ 1000 pM miniglucagon for 2 h incubation

Applications

Miniglucagon dose-dependently (ID50 = 1 pM) inhibited by 80 ~ 100% the insulin release triggered by glucose, glucagon, glucagon-like peptide-1-(7-36) amide (tGLP-1), or glibenclamide. Miniglucagon, at the doses active on insulin release, was able to block the increase in 45Ca2+ uptake induced by depolarizing agents (glucose or extracellular K+), glucagon, or the Ca2+ channel agonist Bay K-8644. In addition, pretreatment with pertussis toxin abolished the effects of miniglucagon on insulin release. These data suggest that miniglucagon is a highly potent and efficient inhibitor of insulin release by closing, via hyperpolarization, voltage-dependent Ca2+ channels linked to a pathway involving a pertussis toxin-sensitive G protein.

Note

The technical data provided above is for reference only.

References:

1. Dalle S, Smith P, Blache P, et al. Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway. Journal of Biological Chemistry, 1999, 274(16): 10869-10876.

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