Gadolinium chloride
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in H2O) | ￥385.00 | 现货 | |
| 50mg | ￥469.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Gadolinium chloride is a CaSR agonist. The CaSR can activate the NLRP3 inflammasome by increasing intracellular Ca2+ and decreasing cellular cyclic AMP. Thus, CaSR agonists may serve as a useful tool for exploring NLRP3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. In addition, gadolinium chloride has been demonstrated to block TRPML channel currents, as well as other transient receptor potential (TRP) channels.
References:
1. Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012, 492(7427): 123-127.
2. Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358.
3. Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.
产品性质
| 物理外观 | A solid |
| CAS号 | 10138-52-0 |
| 分子式 | GdCl3 |
| 分子量 | 263.61 |
| 化学名称 | gadolinium(III) chloride |
| 溶解度 | ≥11.04 mg/mL in DMSO; ≥2.03 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.85 mg/mL in H2O |
| SMILES | Cl[Gd](Cl)Cl |
| 存储条件 | 室温干燥 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 氯化钆是一种钙感受体（CaSR）激动剂 |
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