Fluvastatin Sodium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fluvastatin Sodium是3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶的抑制剂[1]。
Fluvastatin用于治疗高胆固醇血症，它降低血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）以及血清载脂蛋白B的含量，增加高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A-I的含量。此外，Fluvastatin还具有抗动脉粥样、抗血栓形成和抗氧化作用。在U937人单核细胞，Fluvastatin降低粘附分子的表达，从而减少单核细胞和内皮细胞之间的相互作用。Fluvastatin剂量依赖性降低体外血小板聚集。每天给予患者40 mg 剂量的fluvastatin，4到24周后血小板聚集降低10 到15%。在高胆固醇血症患者中，每天给予40 mg fluvastatin连续8周，这些患者中分离的LDL-C中，铜诱导生成的二烯含量减少。有研究表明，fluvastatin可以抑制NO生成，降低海绵基质诱导的炎性血管生成[1,2]。
参考文献：
[1] Langtry HD, Markham A. Fluvastatin. A Review of its Use in Lipid Disorders. Drugs. 1999 Apr;57(4):583-606.
[2] Fernanda A. Araujo, Monaliza A. Rocha, Luciano S. A. Capettini, Paula P. Campos, Monica A. N. D. Ferreira, Virginia S. Lemos1and Silvia P. Andrade. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (uvastatin) decreases inammatory angiogenesis in mice. APMIS. 2012,121:422-430.
| Storage | Store at -20°C |
| M.Wt | 433.45 |
| Cas No. | 93957-55-2 |
| Formula | C24H25FNNaO4 |
| Solubility | ≥16.83 mg/mL in EtOH; ≥18.15 mg/mL in DMSO; ≥8.22 mg/mL in H2O |
| Chemical Name | sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
