ELR510444
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
微管参与核酸和细胞组织\胞内结构的划分和胞内运输以及纤毛和鞭毛运动.微管靶向剂是临床中使用的有效的化学治疗药物.ELR510444是一种新型的微管干扰剂,有多种作用机制.
体外实验:ELR510444具有有效的微管破坏活性,引起细胞内微管的损失和有丝分裂纺锤体的异常形成,最终导致有丝分裂停止和肿瘤细胞的凋亡.ELR510444抑制细胞增殖,有效地抑制纯化微管蛋白组装的速率和程度,从微管蛋白中替换秋水仙碱,表明该药物与微管蛋白的秋水仙素结合位点直接相互作用[1].
在体实验:在MDA-MB-231异种移植模型中,ELR510444具有有效的抗肿瘤活性,具有至少2倍的治疗窗[1].
临床试验:到目前为止,ELR510444还处于临床前开发阶段.
参考文献：
[1] Risinger AL, Westbrook CD, Encinas A, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Mooberry SL. ELR510444, a novel microtubule disruptor with multiple mechanisms of action. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 368.47 |
| Cas No. | 1233948-35-0 |
| Formula | C19H16N2O2S2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥11.9 mg/mL in DMSO |
| Chemical Name | N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(S(NC2=C(C=CC(C3=CC=C(S3)C#N)=C2)C)(=O)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
