Eicosapentaenoic Acid
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ￥527.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Eicosapentaenoic acid is a type of n-3 polyunsaturated fatty acids (n-3 PUFA) [1].
n-3 PUFA are widely used in cardiovascular medicine and lipid-lowering intervention. n-3 PUFA can change the fatty acid composition of the membranes and affect different types of membrane proteins [1].
In endothelial cell line H5V, eicosapentaenoic acid at 100 μM inhibited cell migration into a wound, triggered peripheral distribution of focal adhesions and caused partial disassembly of actin filaments [1]. In addition, at 1 ~ 5 μM, eicosapentaenoic acid inhibited oxidation of very large density lipoprotein in a dose-dependent manner over time [2].
In human subjects with diets high in eicosapentaenoic acid, either as a cod liver oil (40 ml = 4 g eicosapentaenoic acid daily) supplement to their normal Western diet for 24 days, or with mackerel (750 g = 10 ~ 15 g eicosapentaenoic acid daily) as the sole source of protein and lipids, for 3 days, eicosapentaenoic acid increased prostaglandin I3 formation in vivo, providing protection against heart diseases [3].
References:
[1]. Tonutti L, Manzi L, Tacconi M T, et al. Eicosapentaenoic acid inhibits endothelial cell migration in vitro. Journal of angiogenesis research, 2010, 2(12): 1-8.
[2]. Preston Mason R, Sherratt S C R. Eicosapentaenoic acid inhibits oxidation of very large density lipoprotein in a dose-dependent manner over time as compared to docosaheaenoic acid in vitro. Journal of the American College of Cardiology, 2020, 75(11): 2238.
[3]. Evidence of prostaglandin I3 formation in vivo from dietary eicosapentaenoic acid. Nutrition Reviews, 1984, 42(9): 317-318.
产品性质
| 物理外观 | A yellow oil |
| CAS号 | 10417-94-4 |
| 分子式 | C20H30O2 |
| 分子量 | 302.45 |
| 化学名称 | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid |
| 溶解度 | ≥116.8 mg/mL in DMSO; ≥49.3 mg/mL in H2O; ≥52.5 mg/mL in EtOH |
| SMILES | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 二十碳五烯酸（EPA）是一种口服活性欧米加-3 长链多不饱和脂肪酸（ω-3 LC-PUFA）。二十碳五烯酸具有 DNA 去甲基化作用，可促进肿瘤抑制基因 CCAAT/增强子结合蛋白δ（C/EBPδ）的重新表达。二十碳五烯酸通过 H-Ras 内含子 1 CpG 岛的去甲基化激活 U937 白血病细胞中的 RAS/ERK/C/EBPβ 通路。二十碳五烯酸可促进血管平滑肌细胞松弛和血管扩张。 |
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