Cytidine 5-triphosphate
嘧啶核苷三磷酸，RNA合成中的底物
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ￥454.00 | 现货 | |
| 500mg | ￥909.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Cytidine 5-triphosphate (CTP) is a pyrimidine nucleoside triphosphate involved in many biochemical reactions, including RNA synthesis, the formation of phosphatidylcholine (PC), and sialylation. In PC synthesis, CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce cytidine diphosphate-choline (CDP-choline) and diphosphate. This is the rate-limiting step in PC synthesis, and has been implicated in the provision of membranes and bioactive lipids necessary for cell proliferation, contributing to malignant transformation of intestinal epithelial cells. CTP also interacts with N-acylneuraminate in a reaction catalyzed by N-acylneuraminate cytidylyltransferase, generating an intermediate required for sialylation, namely cytidine 5-monophosphate-N-acylneuraminic acid.
References:
1. Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research, 2008, 49(6): 1187-1194.
2. Lagace TA, Ridgway ND. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochimica et Biophysica Acta, 2013, 1833(11): 2499-2510.
3. Arsenault DJ, Yoo BH, Rosen KV, et al. ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells. Journal of Biological Chemistry, 2013, 288(1): 633-643.
4. Vionnet J, Concepcion N, Warner T, et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology, 1999, 9(5): 481-487.
产品性质
| 物理外观 | A solid |
| CAS号 | 65-47-4 |
| 分子式 | C9H16N3O14P3 |
| 分子量 | 483.16 |
| 小分子别名 | Cytidine-5-triphosphate |
| 化学名称 | ((2R,3S,4R,5R)-3,4-dihydroxy-5-(2-hydroxy-4-iminopyrimidin-1(4H)-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate |
| 溶解度 | ≥48.3 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO |
| SMILES | N=C(C=CN1[C@@H]([C@@H]2O)O[C@H](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)[C@H]2O)N=C1O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 胞苷三磷酸（Cytidine5′-triphosphate； 5'-CTP）是一种三磷酸核苷；是核苷酸、核酸和脂质生物合成的基本成分。胞苷三磷酸合成酶可催化尿苷-5′-三磷酸（UTP）形成胞苷-5′-三磷酸。胞苷5′-三磷酸是淋球菌嘧啶从头生物合成途径中必不可少的生物大分子。 |
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