Cyclopiazonic acid
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥1354.00 | 10-15工作日发货 | |
| 10mg | ￥2329.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Cyclopiazonic acid is a neurotoxic secondary metabolite produced by A. flavus and is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA). Cyclobenzoic acid does not inhibit many other types of membrane-bound ATPase, it can effectively inhibit SERCA in intact tissues, smooth muscle and endothelium, and isolated cells[1,2]. It is an effective inducer of plant cell death[3].
References:
[1]. Mumtaz S, Burdyga G, Borisova L, et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium, 2011, 49(1): 66-77.
[2]. Berra-Romani R, Raqeeb A, Torres-Jácome J, et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research, 2012, 49(1): 65-76.
[3]. Chalivendra S C, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact, 2017, 30(5): 361-373.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 18172-33-3 |
| 分子式 | C20H20N2O3 |
| 分子量 | 336.39 |
| 化学名称 | (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one |
| 溶解度 | Soluble in DMSO |
| SMILES | CC(C)([C@@H](C1)[C@@H]([C@@H]2C(O)=C3C(C)=O)c4c[nH]c5cccc1c45)N2C3=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 环罂粟碱是一种内质网钙离子 ATP 酶（ECAs）抑制剂和人类呼吸道合胞病毒（RSV）抑制剂（EC50 值为 4.13 μ M），可降低大鼠胸主动脉 5-HT 受体的拮抗作用，诱导 p53 依赖性细胞凋亡和小鼠睾丸的生殖毒性，抑制黄曲霉毒素 B 的生物活化。</br> |
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