CORM-3

CORM-3是一种水溶性的一氧化碳（CO）释放分子[1]。

作为CO的释放分子，CORM-3通过激活可溶性鸟苷酸环化酶，可模拟血红素加氧酶的抗过敏效应。据报道，CORM-3对心血管炎症有效应。在体外模型中，CORM-3减少PMN诱导的CD54在EC上的表达。CORM-3还具有体外和体内的血管活性性能，作为血管张力和血压的调节剂，具有显著的血管扩张活性。此外，CORM-3也是一种有效的抗微生物剂，通过增加膜通透性和抑制终端氧化酶，从而抑制细菌和酵母病原体的呼吸[1，2，3，4]。

参考文献：
1.  Vannacci A, Marzocca C, Giannini L, Mazzetti L, Franchi-Micheli S, Failli P, Masini E, Motterlini R, Mannaioni PF. Evaluation of the effects of a novel carbon monoxide releasing molecule (CORM-3) in an in vitro model of cardiovascular inflammation. Inflamm Res. 2006 Apr;55.
2.  Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R and Motterlini R. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Cir. Res. 93:e2-e8, 2003.
3.  Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, Motterlini R. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.
4.  Wilson JL, Jesse HE, Hughes B, Lund V, Naylor K, Davidge KS, Cook GM, Mann BE, Poole RK. Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxid Redox Signal. 2013 Aug 10;19(5):497-509.