Cladribine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cladribine是腺苷脱氨酶抑制剂。腺苷脱氨酶是一种参与嘌呤代谢的酶。
Cladribine是一个众所周知的嘌呤核苷类似物,对淋巴增殖性疾病[如毛细胞白血病(HCL)]具有特别的活性。在U266、RPMI8226和MM1.S细胞中,Cladribine以剂量依赖的方式抑制细胞增殖,对三者的IC50值分别为2.43、0.75和0.18 μmol/L。细胞凋亡分析表明Cladribine以剂量依赖的方式诱导U266、RPMI8226和MM11.S细胞凋亡[1]。在MM1.S细胞中,Cladribine (0.2μM)时间依赖性诱导Caspase-3、-8、-9和PARP的裂解,剂量依赖性的减少了STAT3磷酸化水平。同时,Cladribine诱导DNA链断裂的积累,然后激活淋巴细胞的肿瘤抑制基因p53[1]。
在无痛淋巴恶性肿瘤的治疗过程中,低剂量的Cladribine (5毫克/平方米/周)具有高度的性,可能比标准剂量的效果更好[2]。
参考文献:
[1]. Ma J, Wang S, Zhao M, et al. Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer, 2011, 11: 255.
[2]. Robak T, Korycka A, Robak E. Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat Anticancer Drug Discov, 2006, 1(1): 23-38.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 285.69 |
Cas No. | 4291-63-8 |
Formula | C10H12ClN5O3 |
Solubility | ≥41.67 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
Chemical Name | (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol |
SDF | Download SDF |
Canonical SMILES | C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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