Chlorin e6
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Chlorin e6 (Ce6) is a second-generation photosensitizer with antitumor activity when used in conjunction with irradiation.
In a mouse model of implanted fibrosarcoma, Ce6 (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) led to complete tumor loss following varying levels of irradiation[1].
A formulation including Ce6 was tested in a Phase I clinical study for patients with bronchogenic early superficial squamous cell carcinoma with positive results (40 mg/m2, i.v. with laser irradiation at 100 J/cm2)[2]. The same dosing paradigm in a Phase II clinical trial for early stage lung cancer patients led to a complete response in 82.9% of patients[3].
References:
[1]. Katsumi T A, Aizawa K, Kuroiwa Y, et al. Photodynamic therapy with a diode laser for implanted fibrosarcoma in mice employing mono-L-aspartyl chlorin E6. Photochem. Photobiol, 1996, 64(4): 671-675.
[2]. Furukawa K, Okunaka T, Tsuchida T. A phase I clinical study of photodynamic therapy for early stage lung carcinoma using ME2906 and a diode laser system. Porphyrins, 1998, 7: 199-206.
[3]. Kato H, Furukawa K, Sato M, et al. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer, 2003, 42(1): 103-111.
| Storage | Store at -20°C |
| M.Wt | 596.67 |
| Cas No. | 19660-77-6 |
| Formula | C34H36N4O6 |
| Synonyms | Ce6 |
| Solubility | ≤30 mg/mL in DMSO |
| Chemical Name | (7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphine-7-propanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1=C2NC(/C(CC(O)=O)=C(N=C3/C=C4N/C(C(C=C)=C\4C)=C\C5=N/C(C(CC)=C5C)=C\2)/[C@@H](CCC(O)=O)[C@@H]3C)=C1C(O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
