Cefamandole (sodium salt)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 50mg | ￥1975.00 | 10-15工作日发货 | |
| 100mg | ￥3234.00 | 10-15工作日发货 | |
| 500mg | ￥7845.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
MIC: 0.25-2 mg/L for different E. coli strains
Cefamandole is a cephalosporin antibiotic.
The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
In vitro: The in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. Against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. None of the Pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].
In vivo: The testicular toxicity of cefamandole was evaluated in neonatal rats. Results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. In rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].
Clinical trial: A randomized, single-blind comparison of parenteral cefamandole and ampicillin was conducted in adult patients with pneumonia or purulent tracheobronchitis. Results showed that cefamandole was as effective and safe as ampicillin. Of the 14 patients treated with cefamandole, 13 were considered cured, as were 12 of the 13 treated with ampicillin [3].
References:
[1] Eickhoff TC, Ehret JM. In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. Antimicrob Agents Chemother. 1976 Jun;9(6):994-9.
[2] Hoover DM, Buening MK, Tamura RN, Steinberger E. Effects of cefamandole on spermatogenic development of young CD rats. Fundam Appl Toxicol. 1989 Nov;13(4):737-46.
[3] Delgado DG, Brau CJ, Cobbs CG, Dismukes WE. Clinical and laboratory evaluation of cefamandole in the therapy of Haemophilus spp. Bronchopulmonary infections. Antimicrob Agents Chemother. 1979 Jun;15(6):807-12.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 30034-03-8 |
| 分子式 | C18H17N6O5S2·Na |
| 分子量 | 484.5 |
| 小分子别名 | Cefamandole sodium |
| 化学名称 | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt |
| 溶解度 | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| SMILES | C[n]1nnnc1SCC(CS[C@@H]1[C@@H]2NC([C@@H](c3ccccc3)O)=O)=C(C([O-])=O)N1C2=O.[Na+] |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 头孢孟多钠是第二代广谱头孢菌素类抗生素。 |
质量控制
APExBIO 顾客使用本产品发表的 1 篇科研文献
- 1. Feng Long, Yating Chen, et al. "Development of a Multiplex Crystal Digital RT-PCR for Differential Detection of Classical, Highly Pathogenic, and NADC30-like Porcine Reproductive and Respiratory Syndrome Virus." Animals 2023, 13(4), 594.
沪公网安备 31011002003500