Caspofungin
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥1909.00 | 现货 | |
| 5mg | ￥409.00 | 现货 | |
| 10mg | ￥727.00 | 现货 | |
| 50mg | ￥3090.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Caspofungin is an inhibitor of β-1,3-glucan synthase with IC50 value of 0.6 nmol/L in membrane preparations of C. albicans [1, 2].
β-1,3-glucan synthase plays a critical role in biosynthesis of β-(1,3)-D-glucan, an essential cell wall component of many pathogenic fungi that is absent in the mammalian host. Inhibition of β-1,3-glucan synthase provides a potential therapeutic option for treating serious and life-threatening fungal infections [1].
Caspofungin exhibited inhibitory effect against 400 bloodstream Candida species with MIC90 value of 0.25 μg/mL. Moreover, all azole-resistant isolates were susceptible to Caspofungin at concentrations of ≤ 0.5 μg/mL. In addition, Caspofungin showed a postantifungal effect against C. albicans, which lasted for 6 ~ 8 h, at concentrations of 0.125 ~ 1 μg/mL [2].
In 140 patients with mucosal candidiasis, 63% of whom had esophageal involvement and 98% of whom had acquired immunodeficiency syndrome (AIDS), the response rates among the Caspofungin recipients (35, 50, or 70 mg, i.v., q.d., for 7 ~ 14 d) with exclusively oropharyngeal infections was 84% ~ 93%, higher than 67% among those assigned to receive Amphotericin B (0.5 mg/kg, i.v., q.d., for 7 ~ 14 d) [2].
References:
[1]. Leonard W R Jr, Belyk K M, Conlon D A, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. The Journal of Organic Chemistry, 2007, 72(7): 2335-2343.
[2]. Deresinski S C, Stevens D A. Caspofungin. Clinical Infectious Diseases, 2003, 36(11): 1445-1457.
产品性质
| 物理外观 | A solid |
| CAS号 | 162808-62-0 |
| 分子式 | C53H89N9O15 |
| 分子量 | 1092.33 |
| 化学名称 | (2R,6S,11R,12R,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-(11,13-dimethyl-2-oxopentadecyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)hexadecahydro-1H-dipyrrolo[2,1- |
| 溶解度 | ≥48.1 mg/mL in DMSO |
| SMILES | O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 卡泊芬净是一种环脂肽类棘白菌素和β-(1,3)-D-葡聚糖合成酶抑制剂，用于治疗体内或全身真菌病。 |
沪公网安备 31011002003500