Capsazepine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Capsazepine是一种竞争性的辣椒素（capsaicin）受体拮抗剂，IC 50值为562 nM。[1]
Capsazepine是一种合成的capsaicin类似物，其激活TRPV1离子通道，从而阻断辣椒素引起的灼热痛感。Capsazepine阻断成年大鼠背根神经节神经元电压激活的钙电流，EC50值为7.7±1.4 μM。[2]Capsazepine还能够阻断TRPM8对薄荷醇的应答（IC50=18±1.1 μM）。[3] 10 μM 的Capsazepine还抑制大鼠三叉神经节中烟碱乙酰胆碱受体。[4]在人结肠癌细胞中，Capsazepine治疗激活caspase-8、-9和-3诱导的死亡受体（DRS）DR5和DR4，然后致敏细胞对TRAIL诱导的细胞凋亡。[5]Capsazepine被认为是研究TRPV1离子通道的工具。
参考文献：
1. C. S. Walpole, S. Bevan, G. Bovermann, J. J. Boelsterli, R. Breckenridge, J. W. Davies, G. A. Hughes, I. James, L. Oberer, J. Winter and et al., J Med Chem 1994, 37, 1942-1954.
2. R. J. Docherty, J. C. Yeats and A. S. Piper, Br J Pharmacol 1997, 121, 1461-1467.
3. H. J. Behrendt, T. Germann, C. Gillen, H. Hatt and R. Jostock, Br J Pharmacol 2004, 141, 737-745.
4. L. Liu and S. A. Simon, Neurosci Lett 1997, 228, 29-32.
5. B. Sung, S. Prasad, J. Ravindran, V. R. Yadav and B. B. Aggarwal, Free Radic Biol Med 2012, 53, 1977-1987.
| Storage | Store at -20°C |
| M.Wt | 376.9 |
| Cas No. | 138977-28-3 |
| Formula | C19H21ClN2O2S |
| Solubility | ≥18.85 mg/mL in EtOH with gentle warming; insoluble in H2O; ≥22 mg/mL in DMSO with gentle warming |
| Chemical Name | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide |
| SDF | Download SDF |
| Canonical SMILES | C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
