Butaprost
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500ug(solution) | ￥1679.00 | 10-15工作日发货 | |
| 1mg(solution) | ￥2870.00 | 10-15工作日发货 | |
| 5mg(solution) | ￥9370.00 | 10-15工作日发货 | |
| 10mg(solution) | ￥16195.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Butaprost, a structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle[1,2]. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors[3]. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells[4].
References:
[1]. Regan J W, Bailey T J, Pepperl D J, et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol, 1994, 46(2): 213-220.
[2]. Talpain E, Armstrong R A, Coleman R A, et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. British Journal of Pharmacology, 1995, 114(7): 1459-1465.
[3]. Kiriyama M, Ushikubi F, Kobayashi T, et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol, 1997, 122(2): 217-224.
[4]. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. British Journal of Pharmacology, 1992, 105(4): 817-824.
产品性质
| 物理外观 | A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| CAS号 | 69685-22-9 |
| 分子式 | C24H40O5 |
| 分子量 | 408.57 |
| 化学名称 | methyl 7-((1R,2R)-3-hydroxy-2-((S,E)-4-hydroxy-4-(1-propylcyclobutyl)but-1-en-1-yl)-5-oxocyclopentyl)heptanoate |
| 溶解度 | Soluble in DMSO |
| SMILES | CCCC1(CCC1)[C@H](C/C=C/[C@H]([C@@H](CCCCCCC(OC)=O)C(C1)=O)C1O)O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 布他前列素是一种化合物，是前列腺素 E 受体（EP2）的选择性激动剂。它与小鼠 EP2 受体相互作用时的 EC50 为 33 nM，Ki 为 2.4 muM。不过，布他前列素对小鼠 EP1、EP3 和 EP4 受体的活性较低。此外，它还能通过抑制 TGF-beta/Smad2 信号通路有效减轻纤维化。 |
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