Bromocriptine mesylate
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in DMSO) | ￥385.00 | 现货 | |
| 50mg | ￥422.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Bromocriptine Mesylate is a potent, selective D2-like dopamine receptor agonist with pKi of 8.05±0.2. Depending on the D2-like dopamine receptor of the target tissue that Bromocriptine Mesylate binds to, it can decrease metabolic processes leading to glucose intolerance and insulin resistance, inhibit the release of pituitary prolactin, and stimulate motor activity in Parkinson's disease. Bromocriptine Mesylate has been approved for treatment of type 2 diabetes, pituitary prolactinomas, acromegaly and Parkinson's disease.
References:
1. Gardner B, Strange PG. Agonist action at D2(long) dopamine receptors: ligand binding and functional assays. British Journal of Pharmacology, 1998, 124(5): 978-984.
2. Ozery M, Wadhwa R. Bromocriptine. [Updated 2021 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan.
3. Seo EJ, Sugimoto Y, Greten HJ, et al. Repurposing of Bromocriptine for Cancer Therapy. Frontiers in pharmacology, 2018, 9: 1030.
4. Harish Kumar VS, Vinutha MB, Pradeep AN, et al. Bromocriptine, a Dopamine (d2) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub-Therapeutic Doses to Ameliorate Hyperglycaemia. Journal of clinical and diagnostic research, 2013, 7(9): 1904-1907.
产品性质
| 物理外观 | A solid |
| CAS号 | 22260-51-1 |
| 分子式 | C32H40BrN5O5·CH3SO3H |
| 分子量 | 750.7 |
| 化学名称 | (6aR,9R)-5-bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate |
| 溶解度 | insoluble in H2O; insoluble in EtOH; ≥20.05 mg/mL in DMSO |
| SMILES | [H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43.OS(=O)(C)=O |
| 存储条件 | 室温 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 溴隐亭是一种强效多巴胺受体激动剂，与 D2 受体的结合亲和力最高（Ki = 2.5 nM）。 |
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