BMY 14802 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50值:对(+)-[3H]-3-PPP为112 nM.
Sigma受体在精神病中理论上的角色引发了sigma受体的选择性配体作为潜在抗精神病药的发现.BMY 14802是一种sigma受体的配体.
体外实验:BMY 14802对sigma结合位点具有最有效地结合,对血清素亚型1A也有一定程度的结合,对多巴胺受体的结合则可忽略[1].
体内实验:BMY 14802是非典型的标准抗精神病药,其不能诱导大鼠全身僵硬症.此外,该物质对精神病动物模型有效[1].
临床试验:在1周的单盲安慰剂处理后,28个病人使用BMY 14802治疗(高达3000 mg/每天)长达4周.然而,精神症状没有显著改善.使用异常不自主运动量表判断,不自主运动未发生变化,使用辛普森-安格斯量表判断,锥体外系症状也未发生变化[1].
参考文献：
[1] Gewirtz GR, Gorman JM, Volavka J, Macaluso J, Gribkoff G, Taylor DP, Borison R. BMY 14802, a sigma receptor ligand for the treatment of schizophrenia. Neuropsychopharmacology. 1994 Feb;10(1):37-40.
| Physical Appearance | White solid |
| Storage | Desiccate at RT |
| M.Wt | 384.86 |
| Cas No. | 105565-55-7 |
| Formula | C18H22F2N4O·HCl |
| Solubility | <9.62mg/ml in H2O |
| Chemical Name | (R)-1-(4-fluorophenyl)-4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | FC1=CN=C(N=C1)N2CCN(CCC[C@H](C(C=C3)=CC=C3F)O)CC2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
