Blasticidin S HCl是一种抑制蛋白合成的抗生素 [1].

Blasticidin S分离于Streptomyces griseochromogenes,可抑制原核和真核细胞的蛋白质合成.

Blasticidin S HCl是一种抑制蛋白质合成的抗生素.在小鼠白血病L5178Y细胞中,blasticidin S可抑制蛋白质合成,并可导致推定mRNA的降解 [1].并且,blasticidin S可以剂量依赖的方式抑制Dictyostelium discoideum的核糖核酸酶P活性,并可抑制tRNA成熟 [2].在S. cerevisiae中,blasticidin S可抑制半乳糖诱导的蛋白质合成.在Aspergillus parasiticus中,blasticidin S可抑制黄曲霉素的产生,而不抑制真菌生长 [3].在Aspergillus flavus中,blasticidin S显著减少黄曲霉素合成酶 [3].Blasticidin S可有效结合Cu2+离子,保护DNA免遭金属诱发的损伤 [4].Blasticidin S可提高tRNA结合核糖体大亚基的P位点,减缓自发的亚基间轮换.Blasticidin S可抑制肽键形成和肽基-tRNA水解 [5].

参考文献：
[1].  Takenaka K, Endo H, Kuwano M. The synthesis and degradation of presumptive messenger RNA in cultured mouse leukemia cells during the inhibition of protein synthesis. Biochim Biophys Acta, 1978, 521(1): 295-307.
[2].  Stathopoulos C, Tsagla A, Tekos A, et al. Effect of peptidyltransferase inhibitors on ribonuclease P activity from Dictyostelium discoideum. Effect of antibiotics on RNase P. Mol Biol Rep, 2000, 27(2): 107-111.
[3].  Yoshinari T, Noda Y, Yoda K, et al. Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors. J Antibiot (Tokyo), 2010, 63(6): 309-314.
[4].  Stokowa-Sotys K, Jeowska-Bojczuk M. A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage. J Inorg Biochem, 2013, 127: 73-78.
[5].  Svidritskiy E, Ling C, Ermolenko DN, et al. Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome. Proc Natl Acad Sci U S A, 2013, 110(30): 12283-12288.