Bay 11-7821（Bay 11-7082）是IKK的抑制剂，其IC50值为10 μM[1]。

Bay 11-7821可抑制TNFα诱导的IκB-α磷酸化，从而抑制NF-κB，进而抑制TNFα诱发的E-选择素、VCAM-1和ICAM-1的表面表达。据报道，Bay 11-7821并不抑制全部TNFα诱导的磷酸化，只选择性地抑制IκB-α的磷酸化[1]。

实验显示，Bay 11-7821在有效抑制IKK的浓度下具有高毒性。在MM细胞中可抑制细胞坏死。此外，Bay 11-7821通过诱导B细胞淋巴瘤和白血病T细胞的死亡，从而具有抗炎作用。据报道，Bay 11-7821可抑制巨噬细胞中的NALP3炎性复合体[2, 3]。

参考文献：
[1] Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME.  Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103.
[2] Rauert-Wunderlich H1, Siegmund D, Maier E, Giner T, Bargou RC, Wajant H, Stühmer T.  The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors. PLoS One. 2013;8(3):e59292.
[3] Strickson S1, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N, Cohen P.  The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-37.