切换导航
关闭
  • 菜单
  • Setting

Raceanisodamine

 
Catalog No.
C5580
α1肾上腺素受体的弱拮抗剂
组合的产品项目
规格价格库存 数量
250mg
¥ 685.00
现货
500mg
¥ 862.00
现货
1g
¥ 1,370.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

Raceanisodamine is a weak antagonist of α1-adrenergic receptors [1].

The adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. The α1-adrenergic receptors contain three types, termed as α1A-, α1B-, and α1D. The α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function [2]. With the binding of the endogenous ligands, epinephrine and norepinephrine, the adrenergic receptors are the prime mediators of smooth muscle contraction and hypertrophic growth [2].

Raceanisodamine was a natural tropane alkaloid predominantly found in the roots of A. tanguticus. Raceanisodamine weakly antagonized the activity of α1-adrenoceptors and blocked WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively [1]. Raceanisodamine showed antioxidant effects and protected against free radical-induced cellular damage [3].

References:
[1] Varma D R, Yue T L.  Adrenoceptor blocking properties of atropine‐like agents anisodamine and anisodine on brain and cardiovascular tissues of rats[J]. British journal of pharmacology, 1986, 87(3): 587-594.
[2] Piascik M T, Perez D M.  α1-Adrenergic receptors: new insights and directions[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(2): 403-410.
[3] Poupko J M, Baskin S I, Moore E.  The pharmacological properties of anisodamine[J]. Journal of Applied Toxicology, 2007, 27(2): 116-121.

化学属性

StorageStore at -20°C
M.Wt305.37
Cas No.17659-49-3
FormulaC17H23NO4
Synonyms6-hydroxy Hyoscyamine
Solubility≥13.32 mg/mL in EtOH; ≥13.65 mg/mL in H2O; ≥51.3 mg/mL in DMSO
Chemical Name6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
SDFDownload SDF
Canonical SMILESOCC(C(OC1CC(N2C)CC(O)C2C1)=O)C3=CC=CC=C3
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制