Raceanisodamine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 250mg | ￥347.00 | 现货 | |
| 500mg | ￥595.00 | 现货 | |
| 1g | ￥952.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Raceanisodamine is a weak antagonist of α1-adrenergic receptors [1].
The adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. The α1-adrenergic receptors contain three types, termed as α1A-, α1B-, and α1D. The α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function [2]. With the binding of the endogenous ligands, epinephrine and norepinephrine, the adrenergic receptors are the prime mediators of smooth muscle contraction and hypertrophic growth [2].
Raceanisodamine was a natural tropane alkaloid predominantly found in the roots of A. tanguticus. Raceanisodamine weakly antagonized the activity of α1-adrenoceptors and blocked WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively [1]. Raceanisodamine showed antioxidant effects and protected against free radical-induced cellular damage [3].
References:
[1] Varma D R, Yue T L. Adrenoceptor blocking properties of atropine‐like agents anisodamine and anisodine on brain and cardiovascular tissues of rats[J]. British journal of pharmacology, 1986, 87(3): 587-594.
[2] Piascik M T, Perez D M. α1-Adrenergic receptors: new insights and directions[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(2): 403-410.
[3] Poupko J M, Baskin S I, Moore E. The pharmacological properties of anisodamine[J]. Journal of Applied Toxicology, 2007, 27(2): 116-121.
产品性质
| 物理外观 | Solid |
| CAS号 | 17659-49-3 |
| 分子式 | C17H23NO4 |
| 分子量 | 305.37 |
| 小分子别名 | Racanisodamine |
| 化学名称 | 6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate |
| 溶解度 | ≥13.32 mg/mL in EtOH; ≥13.65 mg/mL in H2O; ≥51.3 mg/mL in DMSO |
| SMILES | CN(C(C1)CC(C2)OC(C(CO)c3ccccc3)=O)C2C1O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 拉卡尼索达明是茴香胺的外消旋异构体之一，药理作用与茴香胺相似。拉卡尼索达明是一种非选择性毒蕈碱拮抗剂，用作控制近视的滴眼液成分。 |
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