AH 6809
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AH 6809是前列腺素受体EP1、EP2及D2的拮抗剂[1]。
在转染人EP2受体的COS-7细胞中，AH 6809用药选择性地抑制PGE2，而非毛喉素刺激的cAMP的产生。在非小细胞肺癌NCI-H1299细胞系中，AH 6809抑制3H-PGE2与细胞膜结合，IC50值为5 μM。该化合物也抑制NCI-H1299细胞内PGE2引起的cAMP水平增加。另外，AH 6809在低微摩尔浓度下显著抑制细胞增殖和集落形成。此外，AH 6809可作为一个特异性的DP受体阻滞剂，抑制全血中PGD2的抗聚集活性[1、2及3]。
参考文献：
1. Woodward D F, Pepperl D J, Burkey T H, et al. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2receptor antagonist. Biochemical pharmacology, 1995, 50(10): 1731-1733.
2. Qian X, Zhang J, Liu J. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. Journal of Biological Chemistry, 2011, 286(3): 2111-2120.
3. Ito S, Okuda E, Sugama K, et al. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British journal of pharmacology, 1990, 99(1): 13-14.
- 1. ZHOU Tao, QIAN Yong, et al. "COX-2/PGE2 Activates the JAK/STAT3 Signaling Pathway to Regulate the Proliferation Invasion and Metastasis of KB Cells in Human Oral Cancer." HEIBEI MEDICINE. Vol.27, No.12. Dec., 2021.
- 2. Zhang X, Yan K, et al. "Cyclooxygenase 2 promotes proliferation and invasion in ovarian cancer cells via the PGE2/NF-κB pathway." Cell Transplant. 2019 Dec 10:963689719890597. PMID:31822119
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 298.29 |
| Cas No. | 33458-93-4 |
| Formula | C17H14O5 |
| Synonyms | AH6809;AH-6809 |
| Solubility | Soluble in DMSO |
| Chemical Name | 9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(C)OC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
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