AH 23848 (calcium salt)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mg | ￥1698.00 | 10-15工作日发货 | |
| 5mg | ￥4395.00 | 10-15工作日发货 | |
| 10mg | ￥7032.00 | 10-15工作日发货 | |
| 25mg | ￥13362.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
AH 23848 (calcium salt) is a dual antagonist of TP1 and EP4 receptors [1][2].
The thromboxane receptor (TP), also known as the prostanoid TP receptor, is activated by thromboxane A2 (TXA2). TXA2 is an exceptionally potent inducer of platelet aggregation and of contraction of vascular and respiratory smooth muscle [1]. Prostaglandin E2 (PGE2) subtype receptors (EP) are involved in cellular proliferation and tumor development. Prostaglandin E2 (PGE2) activates four EP receptors, EP1-4. The EP4 receptor is coupled to Gs and mediates increases in cAMP concentration by activation of adenylyl cyclase [4].
AH 23848 (calcium salt) is a dual antagonist of TP1 and EP4 receptors. AH 23848 is an orally active, potent and specific thromboxane receptor-blocking drug that has a long duration of action. AH 23848 inhibited TXA2-induced platelet aggregation and antagonized the contraction of human bronchial smooth muscle induced by the TP agonist U-46619 with pA2 of 8.3 [1][3]. In 3T6 fibroblasts, AH-23848B induced accumulation of cells in early S phase and lowered cyclin A levels [4].
In syngeneic BALB/cByJ female mice injected with line 66.1 or 410.4 tumor cells, AH23848 inhibited the metastasis of line 66.1 and 410.4 cells [5].
References:
[1]. Brittain RT, Boutal L, Carter MC, et al. AH23848: a thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2. Circulation. 1985 Dec;72(6):1208-18.
[2]. Coleman RA, Grix SP, Head SA, et al. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins. 1994 Feb;47(2):151-68.
[3]. Coleman RA, Sheldrick RL. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. Br J Pharmacol. 1989 Mar;96(3):688-92.
[4]. Sanchez, T., and Moreno, J.J. Role of EP1 and EP4 PGE2 subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation. American Journal of Physiology.Cell Physiology 282, C280-C288 (2002).
[5]. Ma X, Kundu N, Rifat S, et al. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Res. 2006 Mar 15;66(6):2923-7.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 81496-19-7 |
| 分子式 | C29H34NO5·1/2Ca |
| 分子量 | 496.6 |
| 小分子别名 | AH23848 hemicalcium salt |
| 化学名称 | (4Z)-rel-7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid, hemicalcium salt |
| 溶解度 | ≤5mg/ml in DMSO |
| SMILES | O=C1C[C@H](OCC2=CC=C(C3=CC=CC=C3)C=C2)[C@H](CC/C=C\CCC([O-])=O)[C@H]1N4CCOCC4.O=C5C[C@H](OCC6=CC=C(C7=CC=CC=C7)C=C6)[C@H](CC/C=C\CCC([O-])=O)[C@H]5N8CCOCC8.[Ca+2] |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | AH23848 半钙化盐是一种强效、特异性和口服活性阻滞剂。AH23848 血钙盐可抑制血小板沉积。 |
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