Acetyl Podocarpic Acid Anhydride
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥1950.00 | 10-15工作日发货 | |
| 10mg | ￥3033.00 | 10-15工作日发货 | |
| 50mg | ￥11375.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Target: LXR
ED50: 1 nM
Acetyl podocarpic acid anhydride (APD) is a kind of potent, semi-synthetic agonist of liver X receptor (LXR), which was derived from the extracts of the mayapple [1].
The liver X receptor is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the farnesoid X receptor (FXR), Peroxisome proliferator-activated receptor (PPARs) and retinoid X receptor (RXR). LXRs are key regulators involved in fatty acid, cholesterol, and glucose homeostasis. APD could inhibit the overall absorption of cholesterol by increasing the efflux of cholesterol from enterocytes, with the ED50 value of 1 nM [2].
In Vitro: In a cell-free assay of receptor activation, APD could cause LXR to bind to SRC-1, with a much more potentiality than 22-(R)-hydroxycholesterol. Besides, in THP-1 human primary hepatocytes, and Caco-2 cells, APD could significantly increase the mRNA level of ABCA1, which was regulated by LXR [2].
In Vivo: no data available.
Clinical trial: no data available.
References:
[1] Costet P, Luo Y, Wang N, et al. Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor[J]. Journal of Biological Chemistry, 2000, 275(36): 28240-28245.
[2] Sparrow C P, Baffic J, Lam M, et al. A potent synthetic LXR agonist is more effective than cholesterol-loading at inducing ABCA1 mRNA and stimulating cholesterol efflux[J]. Journal of Biological Chemistry, 2002, 277(12): 10021-10027.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 344327-48-6 |
| 分子式 | C38H46O7 |
| 分子量 | 614.8 |
| 小分子别名 | Acetyl podocarpic acid anhydride |
| 化学名称 | 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, anhydride |
| 溶解度 | ≤1mg/ml in dimethyl formamide |
| SMILES | CC(=O)Oc1ccc2CC[C@H]3[C@](C)(CCC[C@]3(C)c2c1)[C@@H](=O)O[C@H](=O)[C@@]1(C)CCC[C@]2(C)c3cc(ccc3CC[C@@H]12)OC(=O)C |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 乙酰荚果酸酐是一种强效的半合成肝X受体（LXR）激动剂，从绣线菊提取物中提取。乙酰荚果酸酐具有预防和研究动脉粥样硬化的潜力，尤其是在高密度脂蛋白水平较低的情况下。 |
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