ABT 702 dihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50:腺苷激酶的IC50为1.7 nM.
腺苷(ADO)是一种内源性稳态抑制性神经调节剂,可减少组织损伤和炎症部位的细胞兴奋性.ADO的主要代谢酶,腺苷激酶(AK)的抑制,选择性地增加了组织损伤部位的ADO浓度,提高ADO的镇痛和抗炎作用.ABT 702是一种新型的和强效的非核苷类AK抑制剂.
体外实验:在完整细胞中,ABT 702可抑制AK和ADO磷酸化,抑制AK的IC50为1.7 nM,ADO磷酸化的IC50为50 nM.与ADO行为的其它位点相比,包括ADA\ADO受体和ADO运输位点,ABT 702对AK的抑制具有高度选择性[1].
在体实验:在各种伤害性\炎性和神经性疼痛的动物模型中,ABT 702具有剂量依赖性的抗伤害和抗炎作用.ABT 702是第一个新型有效的和选择性的非核苷类口服活性AK抑制剂,在动物模型中具有有效的镇痛作用[1].
临床试验:到目前为止,ABT 702仍处于临床前开发阶段.
参考文献:
[1] Lee CH, Jiang M, Cowart M, Gfesser G, Perner R, Kim KH, Gu YG, Williams M, Jarvis MF, Kowaluk EA, Stewart AO, Bhagwat SS. Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem. 2001 Jun 21;44(13):2133-8.
Physical Appearance | Orange solid |
Storage | Store at -20°C |
M.Wt | 536.26 |
Cas No. | 1188890-28-9 |
Formula | C22H19N6OBr·2HCl |
Solubility | insoluble in H2O; ≥107.2 mg/mL in DMSO; ≥9.84 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | 5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride |
SDF | Download SDF |
Canonical SMILES | BrC1=CC=CC(C2=CC(C3=CN=C(N4CCOCC4)C=C3)=NC5=NC=NC(N)=C25)=C1.Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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