A-381393
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
A-381393 是一种有效、选择性、可透过血脑屏障的多巴胺D4受体拮抗剂，对人多巴胺D4.4，D4.2和D4.7受体的Ki值分别为1.5，1.9和1.6 nM。A-381393在表达人多巴胺D4.4受体的细胞中有效抑制激动剂诱导的GTP-γ-S结合测定和1 μM多巴胺诱导的Ca2+通量的功能活性，但在人多巴胺D2L或D3受体细胞中无效[1]。A-381393阻断了PD168077产生的c-Fos表达和ERK1/2磷酸化[2]。
参考文献：
[1]. Nakane M, et al. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21. PMID: 15992586
[2]. Bitner RS, et al. Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. Neuropharmacology. 2006 Apr;50(5):521-31. PMID: 16324724
| Storage | Store at -20°C |
| M.Wt | 320.44 |
| Cas No. | 726174-00-1 |
| Formula | C20H24N4 |
| Solubility | ≥16.15 mg/mL in DMSO |
| Chemical Name | 2-((4-(3,4-dimethylphenyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
