DUB
Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).
- A8323 WP11301 CitationSummary: 去泛素化酶(Deubiquitinase,DUB)抑制剂
- A8212 PR-619Target: Deubiquitinating enzymes (DUBs)Summary: 去泛素化酶(DUBs)抑制剂
- A4429 Vialinin ATarget: Deubiquitinating enzymes (DUBs)|IL Receptors|CCL2Summary: USP/IsoT/UCH-L1 DUB抑制剂
- A3823 SJB2-043Target: USPSummary: USP1抑制剂
- A4004 NSC 632839 hydrochlorideSummary: 异肽酶抑制剂
- A4003 LDN 57444Target: UCHSummary: UCH-L1抑制剂
- A4002 IU1Summary: USP14抑制剂
- A3023 P0050911 CitationTarget: Ubiquitin-specific proteasesSummary: 泛素特异性蛋白酶7(USP7)抑制剂
- A8198 P 22077Summary: USP7/(DUB)USP47抑制剂