Immunology/Inflammation
The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
- C6765 4-Aminoantipyrine中文名: 4-氨基安替吡啉
- C6717 Tetrahydroxyquinone中文名: 四羟基苯醌
- C6634 Bendazol
- C6596 Emeramide
- C6525 Butylhydroxyanisole中文名: 丁基羟基茴香醚;叔丁基对羟基茴香醚;丁基大茴醚
- A1035 Papain InhibitorTarget: PapainsSummary: 木瓜蛋白酶抑制剂
- C5785 GardiquimodSummary: 人toll样受体7(TLR7)的激动剂
- C4569 IKK-16 (hydrochloride)Summary: IκB激酶(IKKs)抑制剂
- C4592 ATB-337Summary: H2S供体和NSAID双氯芬酸的杂合分子
- C4277 ML351Summary: 人网织红细胞15-LO-1抑制剂