Immunology/Inflammation - Cancer
The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
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- B5638 ACHPSummary: IκB激酶抑制剂
- B6422 Pyrrolidinedithiocarbamate ammonium1 Citation中文名: 吡咯烷二硫代甲酸铵Summary: NF-κB抑制剂
- B1587 IMD 03541 CitationSummary: IKKβ抑制剂
- B1644 Caffeic Acid Phenethyl Ester中文名: 咖啡酸苯乙酯Summary: NF-κB活化抑制剂
- A3392 Emodin中文名: 大黄素Target: CK2Summary: 天然存在的蒽醌,抗增殖
- A3220 Bardoxolone中文名: 巴多索隆Target: COX|iNOSSummary: 用于治疗慢性肾病,每天一次
- A4210 Bay 11-7821(BAY 11-7082)1 CitationSummary: IKK/NF-κB/TNFα抑制剂
- A2604 Celastrol中文名: 雷公藤红素Target: ProteasomeSummary: 抗氧化、抗炎和免疫抑制剂
- N1846 Tanshinone IIA中文名: 丹参酮IIATarget: AP-1|MAGLSummary: 抗氧化和抗炎剂