Immunology/Inflammation - Cell Experiments
The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
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- B7085 Cardamonin中文名: 豆蔻明Summary: NF-κB抑制剂
- B6853 Ro 106-9920Summary: NF-κB活化抑制剂
- B7199 Withaferin A1 Citation中文名: 醉茄素 ASummary: 通过抑制IKKβ的活化来防止NF-κB活化
- B6422 Pyrrolidinedithiocarbamate ammonium1 Citation中文名: 吡咯烷二硫代甲酸铵Summary: NF-κB抑制剂
- B4655 BMS-345541(free base)Summary: 有效的IKK-1/IKK-2选择性抑制剂
- B3422 U-731221 CitationTarget: PC-PLCSummary: 磷脂酶C,磷脂酶A2和5-LO(5-脂氧合酶)抑制剂
- B1646 ML130 (Nodinitib-1)Target: NOD1Summary: 有效的,选择性的NOD1抑制剂
- B1587 IMD 03541 CitationSummary: IKKβ抑制剂
- B2133 Suprofen中文名: 舒洛芬Target: COXSummary: 双重COX-1/COX-2抑制剂
- B1969 Mesalamine中文名: 美沙拉嗪Summary: IKK抑制剂