BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.
- A4484 PRIMA-1METSummary: 恢复突变p53的活性，诱导BAX和PUMA
- A4483 PRIMA-1Target: p53Summary: BAX抑制剂
- A4462 Bax inhibitor peptide, negative controlSummary: 抑制Bax易位到线粒体的多肽
- A4461 Bax inhibitor peptide V5Target: BaxSummary: Bax抑制剂
- A4460 Bax inhibitor peptide P5Summary: Bax抑制剂
- A4459 Bax channel blockerSummary: Bax介导的线粒体细胞色素c释放的抑制剂
- A3218 BAM7Summary: BAX激活剂