Bax channel blocker
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50：Bax测定中IC50为0.52 μM
Bax channel blocker是一种Bax介导的线粒体细胞色素c释放的抑制剂。
在胞质溶胶中，细胞色素c与dATP、Apaf-1和procaspase-9形成复合物，从而导致caspase 9活化,随后激活下游的其它caspases，如caspase 8，最终导致细胞死亡。Caspase 8裂解后，Bid的15.5 kDa的C末端片段与Bak和Bax相互作用。
体外：Bax channel blocker，一种3,6-二溴咔衍生物，通过调控Bax通道，抑制细胞色素c从线粒体释放。10 μM的一羟基类似物Bax channel blocker仍抑制Bax诱导的细胞色素c释放。Bax channel blocker的IC50值是0.52 μM，表明正如假设，Bax channel blocker是一种Bax通道抑制剂。此外，在脂质体试验中，10 μM的Bax channel blocker显著抑制细胞色素c的释放（> 65％），也显示出亚微摩尔的IC50值[1]。
体内：目前尚未进行Bax channel blocker的动物体内实验。
临床试验：N/A
参考文献：
[1] Bombrun A,Gerber P,Casi G,Terradillos O,Antonsson B,Halazy S. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J Med Chem.2003 Oct 9;46(21):4365-8.
| Physical Appearance | White solid |
| Storage | Desiccate at RT |
| M.Wt | 540.12 |
| Cas No. | 335165-68-9 |
| Formula | C19H21Br2N3O·2HCl |
| Solubility | ≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol;dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
