Catalog No. A8955

Z-YVAD-FMK

Caspase-1抑制剂

规格	价格	货期
1mL(10 mM in DMSO)	￥8272.00	现货
1mg	￥1454.00	现货
5mg	￥3636.00	现货

CAS号：210344-97-1纯度：98%

仅用于科研，不用于诊疗。未经明确授权不得转售。

021-55669583sales@apexbio.cnAPExBIO

特色产品

Annexin V-FITC/PI Apoptosis Kit

用于双染检测细胞凋亡和坏死

- 在10-20分钟内完成染色
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞

Phos binding reagent (Phosbind) acrylamide

分离和检测磷酸化/非磷酸化蛋白

- 新型的磷酸盐结合标签和功能分子
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白

Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

- 比MTT，MTS或WST-1更敏感
- 对细胞无毒性
- 步骤更简单，无需有机溶剂

Cy5 TSA Fluorescence System Kit

Cy5荧光标记的酪胺信号放大系统

- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率

EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)

用于观察mRNA运送，定位，翻译

- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰

HotStart™ 2X Green qPCR Master Mix

用于荧光定量目标DNA或cDNA

- 通过热启动机制优化扩增特异性
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单

HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit Plus

高效的Cy5修饰RNA转录试剂盒

- 适合原位/Northernblot杂交实验
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量

产品描述产品性质生物相关数据质量控制操作说明产品引用文献摩尔浓度计算器

产品描述

Z-YVAD-FMK（CAS号210344-97-1）是一种细胞通透性的、不可逆的caspase-1抑制剂。

在Caco-2细胞中，Z-YVAD-FMK显著降低丁酸对细胞生长的抑制作用。当浓度达到100 μmol/L时，Z-YVAD-FMK完全消除了丁酸的作用。这些结果表明，caspase-1的抑制剂显著改变了caspase级联反应，减弱了丁酸诱导的细胞凋亡效应 [1]。在MyD88缺陷的骨髓树突状细胞中，明矾（Alum）处理诱导caspase-1的激活和IL-1的释放，而Z-YVAD-FMK可以抑制这种效应 [2]。

参考文献：
1. Avivi-Green C, Polak-Charcon S, Madar Z, et al. Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002 Jul;132(7):1812-8.
2. Li H, Nookala S, Re F. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol. 2007 Apr 15;178(8):5271-6.

产品性质

物理外观	Solid
CAS号	210344-97-1
分子式	C₃₁H₃₉FN₄O₉
分子量	630.66
化学名称	(8S,11S,14S)-methyl 14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
溶解度	≥31.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
SMILES	COC(C[C@H](NC([C@H](C)NC([C@@H](NC(C(CC1=CC=C(O)C=C1)NC(OCC2=CC=CC=C2)=O)=O)C(C)C)=O)=O)C(CF)=O)=O
存储条件	-20°C
运输条件	蓝冰

生物相关数据

质量控制

请选择批次查看:

纯度 = 98.00%

COA (Certificate Of Analysis)MS (Retest)NMR (Nuclear Magnetic Resonance)MSDS (Material Safety Data Sheet)

操作说明

小分子化合物通用使用指南 Datasheet

APExBIO 顾客使用本产品发表的 21 篇科研文献

1. Ravi Padia, Lei Sun, et al. "HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression." Cell Death Dis. 2025 Jul 23;16(1):552. PMID: 40701951

2. Hanchao Gao, Yikun Yao, et al. "Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells." Adv Sci (Weinh). 2025 May;12(20):e2411375. PMID: 40213993

3. Xiandong Jiang, Yingying Huang, et al. "Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells." Translational Oncology Volume 52, February 2025, 102227. PMID: 39644823

4. Xueping Li, Jiarui Zhou, et al. "Nucleoside-diphosphate kinase of uropathogenic Escherichia coli inhibits caspase-1-dependent pyroptosis facilitating urinary tract infection." Cell Rep. 2024 Apr 23;43(4):114051. PMID: 38564334

5. Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu, et al. "NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni." bioRxiv. 2024 Mar 13:2024.03.11.584371. PMID: 38559160

6. Jiaxin He, Jialin Cui, et al. "Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis." J Diabetes Res. 2023 May 22:2023:7423661. PMID: 37261217

7. Kempen CG, Deragon MA, et al. "Necroptosis of Lung Epithelial Cells Triggered by Ricin Toxin and Bystander Inflammation." Cell Physiol Biochem 2023 Jan 25;57(1) PMID: 36695077

8. Qian Dai, Xiaolin Liu, et al. "Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response." iScience. 2021 Sep 25;24(10):103170. PMID: 34646996

9. Shouwen Chen, Peng Jin, et al. "Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation." Dev Comp Immunol. 2021 Aug;121:104078. PMID: 33794278

10. Peng Zhang, Boyao Lu, et al. "Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation." J Periodontal Res. 2021 Aug;56(4):667-678. PMID: 33650689

11. Kai J, Yang X, et al. "Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease." Free Radic Biol Med. 2020;153:89-102. PMID: 32289481

12. Ding H, Li Y, et al. "Treatment with 7% and 10% CO2 enhanced expression of IL-1β, TNF-α, and IL-6 in hypoxic cultures of human whole blood." J Int Med Res. 2020;48(4):300060520912105. PMID: 32264730

13. Wang X, Li H, et al. "The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy." Cell Biol Toxicol. 2020;10.1007/s10565-020-09514-8. PMID: 31993881

14. Hodges AL, Kempen CG, et al. "TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin." Toxins (Basel). 2019 Aug 1;11(8). pii: E450. PMID: 31374990

15. Dong X, Zheng Z, et al. "ACPAs promote IL-1βproduction in rheumatoid arthritis by activating the NLRP3 inflammasome." Cell Mol Immunol. 2019 Mar 25. PMID: 30911117

16. Chou X, Ding F, et al. "Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells." Arch Toxicol. 2019 Feb 22. PMID: 30796460

17. Hua S, Ma M, et al. "Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis." Int Immunopharmacol. 2019 Mar;68:145-155. PMID: 30634142

18. Yang D, Zheng X, et al. "Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish." Nat Commun. 2018 Aug 3;9(1):3052. PMID: 30076291

19. Fanfan Xu, Xinghua Qiu, et al. "Effects on IL-1b signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro*." Environmental Pollution 237 (2018) 592e600

20. Kalantari P, Morales Y, Met al. "CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology." Cell Rep. 2018 Jan 30;22(5):1288-1300. PMID: 29386115

21. Ding HG, Deng YY, et al. "Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats." J Neuroinflammation. 2018 Jan 5;15(1):4. PMID: 29304864

摩尔浓度计算器

质量

= 浓度

x 体积

x 分子量

*在配置溶液时，请务必参考产品标签上、MSDS / COA（可在Apexbio的产品页面获得）批次特异的分子量使用本工具。

Z-YVAD-FMK

特色产品

产品描述

产品性质

生物相关数据

质量控制

操作说明

APExBIO 顾客使用本产品发表的 21 篇科研文献

摩尔浓度计算器

相关产品

Z-YVAD-FMK

特色产品

产品描述

产品性质

生物相关数据

质量控制

操作说明

APExBIO 顾客使用本产品发表的 21 篇科研文献

摩尔浓度计算器

相关产品

美国APExBIO中文官网