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Z-Asp-CH2-DCB

 
Catalog No.
C4981
caspase抑制剂
组合的产品项目
规格价格库存 数量
5mg
¥ 1,300.00
Ship with 10-15 days
10mg
¥ 1,895.00
Ship with 10-15 days
25mg
¥ 3,900.00
Ship with 10-15 days
50mg
¥ 6,283.00
Ship with 10-15 days

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A

背景

Z-Asp-CH2-DCB is an inhibitor of ICE/Ced-3 family proteases [1].

Caspases (ICE/ Ced3 proteases) play key biological roles in inflammation and mammalian apoptosis. Caspases are a closely related family of cysteine proteases that play a key role in apoptotic cell death. Activation of Caspases shows important roles in programmed cell death such as pyroptosis and necroptosis to protect cells from stress signals and pathogenic attack. Caspases play an important role in inflammation. Caspases have also been involved in cell proliferation, cell differentiation, tumour suppression, neural development and axon guidance and ageing. Deficiency in caspase results in tumour development. Overactivation of some caspases can lead to excessive programmed cell death, such as caspase-3 [2].

Z-Asp-CH2-DCB blocked apoptosis in U937 cells triggered by antitumor agents. Z-Asp-CH2-DCB also blocked apoptosis in IFN-γ-pretreated cells. Z-Asp-CH2 -DCB completely inhibited DNA fragmentation induced by γ-irradiation, antitumor agents, or anti-Fas antibody [1].

References:
[1] Tamura T, Ueda S, Yoshida M, et al.  Interferon-γ InducesIceGene Expression and Enhances Cellular Susceptibility to Apoptosis in the U937 Leukemia Cell Line[J]. Biochemical and biophysical research communications, 1996, 229(1): 21-26.
[2] Brker L E, Kruyt F A E, Giaccone G.  Cell death independent of caspases: a review[J]. Clinical Cancer Research, 2005, 11(9): 3155-3162.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt454.3
Cas No.153088-73-4
FormulaC20H17Cl2NO7
SynonymsZ-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
Solubility≤33mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
Chemical Name(3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid
SDFDownload SDF
Canonical SMILESClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

Z-Asp-CH2-DCB