Y-320
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Y-320是新型苯基吡唑苯胺类免疫调节剂[1].
免疫治疗是指通过抑制\诱导或增强免疫应答达到治疗疾病的目的.
Y-320是新型苯基吡唑苯胺类免疫调节剂.Y-320抑制IL-15刺激的CD4 T细胞产生IL-17,IC50值为20-60 nM [1].
在II型胶原诱导的关节炎(CIA)小鼠中,口服Y-320 (0.3-3 mg/kg)降低IL-17 mRNA的表达,并显著抑制关节损伤和关节炎的发展.Y-320与抗鼠肿瘤坏死因子α(TNF-α)单克隆抗体联合给药具有协同效应.在猕猴中,Y-320 (0.3-1 mg/kg)能够减轻CIA.这些结果表明Y-320可以作为类风湿性关节炎(RA)治疗的有效候选药[1].
参考文献：
[1]. Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel), 2013, 7(1): 1-17.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 505.01 |
| Cas No. | 288250-47-5 |
| Formula | C27H29ClN6O2 |
| Solubility | ≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C=NN1C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCOCC5)C#N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | Y-320是口服有效的免疫调节剂,抑制IL-15刺激的CD4 T细胞产生IL-17,IC50值为20-60 nM. | |||||
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| IC50 | ||||||
