XE 991 dihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
XE991 dihydrochloride是Kv7 (KCNQ)通道的阻滞剂，可有效抑制KCNQ1 (Kv7.1)、KCNQ2 (Kv7.2)、KCNQ2 + KCNQ3 (Kv7.3)通道和M-current，IC50值分别为0.75 μM 、0.71 μM、0.6 μM 和 0.98 μM，分别[1]。 XE 991 dihydrochloride 可增强大鼠脑切片中 [3H]ACh 的释放，并显示出更长的体内功效和作用持续时间[2]。
参考文献：
[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. PMID: 9836639
[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. PMID: 9580619
| Storage | Store at -20°C |
| M.Wt | 449.38 |
| Cas No. | 122955-13-9 |
| Formula | C26H22Cl2N2O |
| Solubility | ≥10.95 mg/mL in DMSO with ultrasonic |
| Chemical Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
