Thioguanine

硫鸟嘌呤（CAS号154-42-7）是硫嘌呤类免疫调节剂及抗肿瘤 / 抗病毒药物，作用靶点包括次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶（HGPRT）、DNMT1，IC₅₀覆盖多场景：抗 EV71 病毒（HT-29 细胞）为 0.9302 μM（SI>2150.1），抗肿瘤（MCF-7 乳腺癌细胞）为 5.481~23.09 μM、PA-1 卵巢癌细胞为 3.92~5.81 μM，白血病细胞（T-cell ALL）LC₅₀为 5.0 μg/ml；临床核心用于对 AZA/MP 不耐受或无效的 IBD 患者，口服起始及维持剂量为 20 mg / 天，可按耐受性调整至 10~80 mg / 天，低剂量（≤20 mg / 天）肝毒性风险低；体外实验中，抗病毒有效浓度 0.5~3 μM、抗肿瘤有效浓度 3.92~23.09 μM。

参考文献：

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