SW106065
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SW106065是MPNST（恶性周围神经鞘瘤）的细胞凋亡诱导剂。SW106065 抑制sMPNST和其他MPNST模型（EC50：1 µM）的 ATP 消耗。 SW106065以剂量依赖性方式抑制人 MPNST细胞系的生长。S462和SNF96.2 细胞的EC50分别为439 nM和753.6 nM。 然而，SW106065对正常分裂的雪旺氏细胞或小鼠胚胎成纤维细胞无毒。SW106065（40 mg/kg；腹腔注射；每天两次，持续4周）可以以足以穿透 sMPNST 组织并抑制肿瘤发展的浓度给予小鼠[1]。
参考文献：
[1]. Vincent Chau, et al. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 2014 Jan 15;74(2):586-97. PMID: 24285727
| Storage | Store at -20°C |
| M.Wt | 204.25 |
| Cas No. | 62289-81-0 |
| Formula | C10H8N2OS |
| Solubility | ≥30 mg/mL in DMSO |
| Chemical Name | N-(pyridin-3-yl)thiophene-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC=CS1)NC2=CC=CN=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
