SR 202
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50：对减弱曲格列酮诱导的过氧化物酶体增殖物激活受体γ（PPARγ）转录活性的IC50为140 μM [1]
膦磷酸盐SR-202 [（S）-（4-氯苯基）（二乙氧基磷酸基）甲基二甲基磷酸酯]是一种PPARγ拮抗剂，其抑制TZD刺激的共活化剂类固醇受体共激活因子-1的募集作用，以及TZD诱导的受体转录活性。PPARγ是一种核受体，调节葡萄糖代谢和脂肪酸存储。
体外：SR-202是一种特异性的PPARγ拮抗剂，在PPAR家族成员和其他核受体之间具有选择性。SR-202也抑制脂肪细胞的PPARγ依赖性分化。在细胞培养中，SR-202有效拮抗激素和TZD诱导的脂肪细胞分化[1]。
体内：用SR-202治疗降低PPARγ活性，导致高脂饮食诱导的脂肪细胞肥大及胰岛素抵抗的降低。用SR-202治疗也显著改善糖尿病ob/ob小鼠的胰岛素敏感性[1]。野生型小鼠饲喂高脂饮食时，TNF-α的血浆水平升高，SR-202治疗防止这种升高[2] ..
临床试验：目前尚未进行临床研究。
参考文献：
[1] Rieusset J, Touri F, Michalik L, Escher P, Desvergne B, Niesor E, Wahli W. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol. 2002 Nov;16(11):2628-44.
[2] Doggrell S. Do peroxisome proliferation receptor-gamma antagonists have clinical potential as combined antiobesity and antidiabetic drugs Expert Opin Investig Drugs. 2003 Apr;12(4):713-6.
| Physical Appearance | White solid |
| Storage | Desiccate at RT |
| M.Wt | 358.65 |
| Cas No. | 76541-72-5 |
| Formula | C11H17ClO7P2 |
| Solubility | ≥50.8 mg/mL in DMSO; ≥50.4 mg/mL in EtOH; ≥51.1 mg/mL in H2O |
| Chemical Name | (S)-(4-chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate |
| SDF | Download SDF |
| Canonical SMILES | ClC1=CC=C(C=C1)[C@@H](OP(OC)(OC)=O)P(OC)(OC)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
