Spermine NONOate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Spermine NONOate是二醇二氮烯类一氧化氮供体[1]。
一氧化氮（NO）增加细胞内鸟苷3'5'环一磷酸，激活鸟苷酸环化酶，然后导致血管平滑肌松弛[1]。
Spermine NONOate是二醇二氮烯类一氧化氮供体。在大鼠肺动脉环中，Spermine NONOate（100 μM）促进鸟苷3'5'环磷酸（cyclic GMP）增加35倍，通过激活肌浆-内质网Ca2+-ATPase、Na+/K+-ATPase和Ca2+激活的K通道导致cyclic GMP依赖性的舒张[1]。Spermine NONOate抑制硫酸铜诱导的人低密度脂蛋白（LDL）氧化[2]。
在大鼠双侧子宫角损伤中，spermine NONOate (1 mg)抑制粘连的形成。此外，N,O-carboxymethylchitosan (NOCC)与spermine NONOate联合使用比spermine NONOate单独使用严重性较低。这些结果表明，spermine NONOate减少了术后粘连[3]。
参考文献：
[1]. Homer KL, Wanstall JC. Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor. Br J Pharmacol, 2000, 131(4): 673-682.
[2]. Goss SP, Hogg N, Kalyanaraman B. The antioxidant effect of spermine NONOate in human low-density lipoprotein. Chem Res Toxicol, 1995, 8(5): 800-806.
[3]. Duran B, Ak D, Cetin A, et al. Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in rats. Exp Anim, 2003, 52(4): 267-272.
| Physical Appearance | A crystalline solid |
| Storage | Store at -80°C |
| M.Wt | 262.35 |
| Cas No. | 136587-13-8 |
| Formula | C10H26N6O2 |
| Solubility | Soluble in H2O |
| Chemical Name | N'-(3-aminopropyl)-N'-(4-((3-aminopropyl)amino)butyl)-N-hydroxynitrous hydrazide |
| SDF | Download SDF |
| Canonical SMILES | ON(N=O)N(CCCN)CCCCNCCCN |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
