Geranylgeranyl Pyrophosphate (ammonium salt)
用于蛋白质香叶酰化及二萜类化合物合成的中间体。
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 250ug(solution) | ￥1225.00 | 7-15工作日发货 | |
| 500ug(solution) | ￥2050.00 | 7-15工作日发货 | |
| 1mg(solution) | ￥3150.00 | 7-15工作日发货 | |
| 5mg(solution) | ￥9288.00 | 7-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids[1]. It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases[2]. This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery[3,4].
References:
[1]. Vance D E. Cholesterol and related derivatives. Biochemistry 2nd ed, 1988, 725-748.
[2]. McTaggart S J. Isoprenylated proteins. Cell Mol.Life Sci, 2006, 63(3): 255-267.
[3]. Baron R A, Seabra M C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal, 2008, 415(1): 67-75.
[4]. Maynor M, Scott S A, Rickert E L, et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters, 2008, 18(6): 1889-1892.
产品性质
| 物理外观 | A solution in methanol:ammonium hydroxide (70:30). To change the solvent, simply evaporate the methanol:ammonium hydroxide (70:30) containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| CAS号 | 313263-08-0 |
| 分子式 | C20H45N3O7P2 |
| 分子量 | 501.53 |
| 化学名称 | ammonium (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl diphosphate |
| 溶解度 | Soluble in DMSO |
| SMILES | C/C(CC/C=C(C)\C)=C\CC/C(C)=C/CC/C(C)=C/COP(OP([O-])([O-])=O)([O-])=O.[NH4+].[NH4+].[NH4+] |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 香叶基焦磷酸酯是 HMG-CoA 还原酶途径中的一种中间体；直接来自焦磷酸法呢基；用于萜烯和萜类化合物的生物合成。它也是包括小 GTP 酶在内的多种关键细胞内蛋白质进行前炔化时的底物。这种翻译后修饰是蛋白质正确定位到细胞内膜以发挥适当功能的必要条件；并已成为抗癌药物发现的重点。 |
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